Posts Tagged ‘cheap antidepressants’

Some people are resistant to antidepressants.

Wednesday, January 13th, 2010

New research is giving scientists a greater understanding of how a brain becomes susceptible to depression and anxiety on a molecular level and why some people are resistant to antidepressants.

Scientists think two things — biological factors and stressful life events — cause the mental disorders. Antidepressants are available to treat them, often by increasing serotonin levels, but they don’t always work.

“Unfortunately, more than half of all depressed patients fail to respond to their first drug treatment,” senior study author Rene Hen, of Columbia University, said in a news release. “The reasons for this treatment resistance remain enigmatic. Elucidating the exact nature of both the factors predisposing to depression and the mechanisms underlying treatment resistance remains an important and unmet need.”

In the study, researchers used mice to investigate the way the brain deals with serotonin. The brain’s mechanism for handling serotonin appears to be related to levels of so-called “autoreceptors,” the study authors found. Mice with higher levels didn’t respond to treatment with antidepressants, but they did better when the levels went down, the study showed.

The research could lead to treatments to make people more responsive to antidepressants before they take them, Hen said.

Stress & Food

Monday, November 30th, 2009

HE secret of why comfort food tastes so good may be all in the mind, experts say.
Foods that are high in fat and sugar appear to be able to change the chemicals in the brain and aid relaxation.
Comfort foods may even reverse the anxiety triggered by stressful memories, a study suggests.
Scientists believe the research could lead them to understand why we feel unhappy and how this affects our behaviour.
It is already known that food can make us feel better. Dishes rich in carbohydrates, such as mashed potato or creamy pasta, boost levels of a mood chemical in the brain called seratonin.
The study in Australia suggests there may be an even more complex relationship between food and the brain. Published in a scientific journal, the findings say that trauma in early life can alter the way that nerves form in the brain. This could lead later in life to more feelings of stress and anxiety.
But a diet rich in fat and sugar seemed to balance these changes and ultimately provide the comfort food lift many people seek.
Margaret Morris, professor of pharmacology at New South Wales university where the study was carried out, said the results were exciting. She believes early studies in rats may provide a similar result in later research with humans.
“We are able to reverse a behavioural deficit that was caused by a traumatic event early in life, simply through a dietary intervention,” she said. “Many neurological diseases appear to have their origins early in life. Stress hormones definitely affect the way nerve cells grow in the brain. This discovery may be giving us a clue about a different way to tackle a range of conditions that affect mood and behaviour.”
In the study, laboratory rats were isolated from their mothers to cause stress or given normal maternal love. The researchers found that those who were separated suffered more stress and had higher levels of stress hormones in their bodies. But when they were fed high fat foods, the levels of stress and anxious behaviour dropped.
Professor Morris said the findings could suggest comfort food works in a similar way to anti-depressants.
“Eating palatable food seems to affect neurogenesis similar to the way anti-depressants promote nerve growth in the brain,” she said.

Still depressed?

Friday, August 21st, 2009

1. Omega-3 Fatty Acids

Because the brain needs a steady supply of omega-3s to function properly, people who don’t eat enough of these fats are at increased risk for many forms of mental illness, including depression. Across the globe, countries with the highest level of omega-3 consumption typically have the lowest rates of depression.

Clinical researchers have even started using omega-3 supplements to treat depression, and the results so far have been highly encouraging. For example, British researchers recently studied a group of depressed patients who had failed to recover after taking antidepressant medication for eight weeks. All study patients stayed on their meds as prescribed, but some also took an omega-3 supplement. About 70 percent of those who received the supplement went on to recover, compared with only 25 percent of patients who kept taking only the medication. This study–along with a handful of others like it–suggests that omega-3s may be among the most effective antidepressant substances ever discovered.

2. Engaged Activity

The biggest risk factor for rumination is simply spending time alone, something Americans now do all the time. When you’re interacting with another person, your mind just doesn’t have a chance to dwell on repetitive negative thoughts. But, really, any sort of engaged activity can work to interrupt rumination. It can even be something simple.

3. Physical Exercise

Researchers have compared aerobic exercise and Zoloft head to head in the treatment of depression. Even at a low “dose” of exercise–thirty minutes of brisk walking three times a week–patients who worked out did just as well as those who took the medication. Strikingly, though, the patients on Zoloft were about three times more likely than exercisers to become depressed again over a ten-month follow-up period.

There are now over a hundred published studies documenting the antidepressant effects of exercise. Activities as varied as walking, biking, jogging, and weight lifting have all been found to be effective. It’s also becoming clear just how they work. Exercise changes the brain. It increases the activity level of important brain chemicals such as dopamine and serotonin (the same neurochemical targeted by popular drugs like Zoloft, Prozac, and Lexapro). Exercise also increases the brain’s production of a key growth hormone called BDNF. Because levels of this hormone plummet in depression, some parts of the brain start to shrink over time, and learning and memory are impaired. But exercise reverses this trend, protecting the brain in a way nothing else can.

4. Sunlight Exposure

A deeper link exists between light exposure and depression–one involving the body’s internal clock. The brain gauges the amount of light you get each day, and it uses that information to reset your body clock. Without light exposure, the body clock eventually gets out of sync, and when that happens, it throws off important circadian rhythms that regulate energy, sleep, appetite, and hormone levels. The disruption of these important biological rhythms can, in turn, trigger clinical depression.

Because natural sunlight is so much brighter than indoor lighting–over a hundred times brighter, on average–a half hour of sunlight is enough to reset your body clock. Even the natural light of a gray, cloudy day is several times brighter than the inside of most people’s houses, and a few hours of exposure provide just enough light to keep circadian rhythms well regulated.

5. Social Support

The research on this issue is clear: When it comes to depression, relationships matter. People who lack a supportive social network face an increased risk of becoming depressed, and of remaining depressed once an episode strikes. Fortunately, we can do a great deal to improve the quality and depth of our connections with other and this can have a huge payoff in terms of fighting depression and reducing the risk of recurrence.

6. Sleep

When sleep deprivation continues for days or weeks at a time, it can interfere with our ability to think clearly. It can even bring about serious health consequences. Disrupted sleep is one of the most potent triggers of depression, and there’s evidence that most episodes of mood disorder are preceded by at least several weeks of subpar slumber.

Help yourself now!